A newly developed assay based on chemically induced premature chromosome condensation (PCC) and multi−color combined binary ratio labeling (COBRA) fluorescence in situ hybridization (FISH) techniques have been implemented in order to investigate for the first time for recurrent cytogenetic aberrations in primary cervical carcinoma (derived directly from biopsies) at different stages of progression. »
01/01/10

HJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with centromere protein A (CENP−A). However its role in tumor development remains largely unknown. The goal of this study was to investigate the clinical significance of HJURP in breast cancer and its correlation with radiotherapeutic outcome. »
03/08/10

This study evaluates the relation of the early oestrogen−regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma. »
03/02/10

Overexpression of ErbB2 receptor in breast cancer is associated with disease progression and poor prognosis. Trastuzumab, the only humanised anti−ErbB2 antibody currently used in breast cancer, has proven to be effective; however, a relevant problem for clinical practice is that a high fraction of breast cancer patients shows primary or acquired resistance to trastuzumab treatment. »
02/02/10

Class III beta−tubulin overexpression is a marker of resistance to microtubule disruptors in vitro, in vivo and in the clinic for many cancers, including breast cancer. The aims of this study were to develop a new model of class III beta−tubulin expression, avoiding the toxicity associated with chronic overexpression of class III beta−tubulin, and study the efficacy of a panel of clinical and pre−clinical drugs in this model. »
01/19/10

Inhibitors of differentiation or DNA binding (Id) proteins have been shown to be involved in tumor growth, invasiveness, metastasis, and angiogenesis. Overexpression of Id proteins, especially Id1, correlates with unfavorable clinical prognosis. »
02/27/10

Phospholipase D (PLD) has emerged as a critical element in the cell growth signaling. Despite extensive information regarding the regulation of PLD activity in cell survival, the signaling mechanisms that regulate PLD expression in cancer remains poorly understood. »
02/24/10

Homocysteine and cysteine are associated with oxidative damage and metabolic disorders, which may lead to carcinogenesis. Observational studies assessing the association between circulating homocysteine or cysteine and breast cancer are very limited, and findings have been inconsistent. »
03/02/10

The cell cycle regulating protein p27(Kip1) (p27) has dual roles by acting as both a cdk−inhibitor and as an assembly factor for different cdk−complexes. Loss of p27 has been linked to malignant features in tumours, however the exact role of p27 deregulation in breast cancer regarding prognostic and treatment predictive information has not been fully clarified. »
03/03/10

Cancer cells upregulate glycolysis, increasing glucose uptake to meet energy needs. A small fraction of a cell's glucose enters the hexosamine biosynthetic pathway (HBP), which regulates levels of O−linked beta−N−acetylglucosamine (O−GlcNAc), a carbohydrate posttranslational modification of diverse nuclear and cytosolic proteins. »
03/01/10