Sulforaphane (SFN), an isothiocyanate phytochemical present predominantly in cruciferous vegetables such as brussels sprouts and broccoli, is considered particularly promising as a chemo−preventive agent against cancer because it induces apoptosis and cell−cycle arrest in a variety of tumor types. Molecular mechanisms leading to the inhibition of cell cycle progression by SFN are poorly understood in epithelial ovarian cancer (EOC). The aim of this study is to understand the signaling mechanisms through which SFN influences the cell growth and proliferation in EOC. »
03/02/10

Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter−individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT−11) is worldwide approved for the treatment of metastatic colorectal cancer and undergoes extensive peripheral and tumoral metabolism. PXR is a xenoreceptor activated by many drugs and environmental compounds regulating the expression of drug metabolism and transport genes in detoxification organs such as liver and gastrointestinal tract. Considering the metabolic pathway of irinotecan and the tissue distribution of Pregnane X Receptor (PXR), we hypothesized that PXR could play a key role in colon cancer cell response to irinotecan. »
03/02/10

HAX−1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexpression in cancer cell lines and tumors suggests that HAX−1 may play a role in neoplastic transformation. Here we present the first systematic analysis of HAX−1 expression in several solid tumors. »
03/02/10

Epigenetic alterations including changes to cellular DNA methylation levels contribute to carcinogenesis and may serve as powerful biomarkers of the disease. This investigation sought to determine whether hypomethylation at the long interspersed nuclear elements (LINE1), reflective of the level of global DNA methylation, in peripheral blood−derived DNA is associated with increased risk of bladder cancer. »
03/01/10

HAMLET is a protein−lipid complex that kills different types of cancer cells. Recently we observed a rapid reduction in human bladder cancer size after intravesical HAMLET treatment. In this study we evaluated the therapeutic effect of HAMLET in the mouse MB49 bladder carcinoma model. »
02/19/10

To evaluate the safety, tolerability and efficacy of adjuvant intravesical gemcitabine versus bacillus Calmette−Guérin (BCG) in the treatment of high−risk superficial bladder cancer. »
02/17/10

Human papillomavirus (HPV), particularly type 16, has been associated with more than 99% of cervical cancers. There are two HPV oncogenic proteins, E6 and E7, which play a major role in the induction and maintenance of cellular transformation. »
01/02/10

Obesity and depression may each be associated with lower rates of cervical and breast cancer screening. Studies have examined obesity or depression alone, but not together, despite the established link between them. »
03/01/10

The aim of this study was to determine prevalence of and experienced distress from pelvic floor symptoms in cervical cancer survivors (CCS). »
02/17/10

To estimate the safety of fertility-conserving surgery for stage IA1 cervical cancer and to analyze predictors of access to conization. »
03/01/10