With the exception of the laying hen, no other animal model of spontaneous ovarian surface epithelial cancer replicates the human disease. Flaxseed is the richest vegetable source of omega−3 fatty acids, which are chemopreventive in breast cancer and may be important in other cancers. The objective of this study was to determine if a flaxseed−enriched diet had a chemopreventive effect on ovarian cancer in the laying hen. »
02/12/10

There is a close correlation between tumour progression and hyaluronan production, either by tumour cells or stromal cells that are stimulated by tumour−derived factors. Inhibition of tumour stimulation of fibroblast hyaluronan may suppress tumour growth and invasion. »
02/15/10

Copy gains involving chromosome 7p represent one of the most common genomic alterations found in melanomas, suggesting the presence of "driver" cancer genes. We identified several tumor samples that harbored focal amplifications situated at the peak of common chromosome 7p gains, in which the minimal common overlapping region spanned the ETV1 oncogene. »
03/01/10

Preclinical data indicate that there is substantial antitumor activity and synergy between calcitriol and dexamethasone. On the basis of these data, the authors conducted a phase 2 trial of intravenous (iv) calcitriol at a dose of 74 mug weekly (based on a recent phase 1 trial) and dexamethasone in patients with castration−resistant prostate cancer (CRPC). »
02/17/10

Snail transcription factor induces epithelial−mesenchymal transition (EMT) via decreased cell adhesion−associated molecules like E−cadherin, and increased mesenchymal markers like vimentin. We previously established Snail−mediated EMT model utilizing androgen−dependent LNCaP cells. These cells express increased vimentin protein and relocalization of E−cadherin from the cell membrane to the cytosol. Interestingly, Snail transfection in LNCaP cells resulted in cells acquiring a neuroendocrine (NE)−like morphology with long neurite−like processes. »
02/17/10

Seladin−1 belongs to a subgroup of androgen−dependent genes associated with anti−proliferative, pro−differentiation, and pro−apoptotic functions and plays a protective role against oncogenic stress. The present study aims to investigate the localization and expression of Seladin−1 protein in normal and tumoral human prostatic tissues as well as to explore its role in proliferation and steroid secretion in androgen−dependent (LnCaP) and androgen−independent (DU145) cell lines and in human prostate primary cell culture. »
02/17/10

Lung cancer is the leading cause of cancer−related mortality among women. The role of hormone replacement therapy (HRT) in lung cancer development is unclear. »
02/16/10

To compare the efficacy and toxicities of chemotherapy plus cetuximab (Erbitux, E; E−chemo) with chemotherapy alone (chemo alone) in patients with previously untreated advanced non−small−cell lung cancer (NSCLC). The primary endpoint was overall survival; the secondary endpoints were progression−free survival, overall response rate, one−year survival and safety. »
02/09/10

Tissue inhibitor of metalloproteinases−1 (TIMP−1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP−1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP−1 levels in comparison with carcinoembryonic antigen (CEA) levels in patients with stage III colon cancer. »
01/01/10

Due to advanced chemotherapy regimens, patients presenting with residual liver metastases of colorectal cancer (CRC) has increased. Surgery of residual metastases enhances overall survival, but surgical resection is often limited. Less invasive techniques have been invented to enhance local disease control. We investigated in a selected patient cohort local control of liver metastasis from CRC using robotic radiosurgery. »
02/12/10