An increased incidence of colorectal carcinoma is known to occur in patients with ulcerative colitis, which displays a cycle of recurrence−remission in the colorectal mucosa. »
11/23/09

Pure signet−ring cell colorectal carcinoma (SRCC) is an infrequent and highly malignant histological variant of colorectal cancer (CRC), while it is present as a histological component in colorectal carcinomas more frequently. »
11/23/09

The aims of this prospective study were 1) to evaluate the accuracy of high−resolution three−dimensional endorectal ultrasonography in distinguishing slight from massive submucosal invasion of early rectal tumors, and 2) to determine the technology's role in treatment selection. »
11/23/09

The prognostic significance of circulating (CTC) and disseminated tumor cells (DTC) in patients with colorectal cancer (CRC) is controversial. We performed a meta−analysis of available studies to assess whether the detection of tumor cells in the blood and bone marrow of patients diagnosed with primary CRC can be used as a prognostic factor. »
01/22/10

Resistance to platinum drugs has emerged as a major obstacle in the treatment of ovarian cancers. Through proteomic analysis, we have found that the expression of annexin A3, a member of the Ca(2+) and phospholipid−binding annexin family, is significantly increased in platinum−resistant ovarian cell lines. »
01/26/10

Our work was undertaken to determine the usefulness ofYKL−40 as a tumor marker in patients with ovarian cancer and women with BRCA 1 gene mutations. »
11/23/09

Role of microRNAs in malignancies is well established due their regulatory role in cellular differentiation, proliferation and cell cycle control. Our purpose was to determine miRNA profiles of serially established ovarian cancer cell lines and the effect of genistein treatment. »
12/23/09

To evaluate the prognostic significance for overall survival rate for the marker combination TPS and CA125 in ovarian cancer patients after three chemotherapy courses during long−term clinical follow−up. »
12/23/09

Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in ovarian tumorigenesis. Mutational activation of one member of this receptor family, FGFR2, is a frequent event in endometrioid endometrial cancer. Given the similarities in the histologic and molecular genetics of ovarian and endometrial cancers, we hypothesized that activating FGFR2 mutations may occur in a subset of endometrioid ovarian tumors, and possibly other histotypes. »
01/25/10

Sanguinarine is a benzophenanthridine alkaloid, derived from the root of Sanguinaria canadensis and other poppy Fumaria species, which is known to have antimicrobial, antiinflammatory and antioxidant properties. Tumor necrosis factor−related apoptosis−inducing ligand (TRAIL) is known to induce apoptosis in cancer cells but spare most normal cells. »
11/24/09