Macrophage inhibitory cytokine−1(MIC−1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago−gastric cancer (OGC) »
01/26/10

Helicobacter pylori−induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase−7 (MMP−7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP−7 in gastric epithelial cells in vitro. »
01/01/10

Aloe−emodin, one of the anthraquinones, has been shown to have anticancer activity in different kinds of human cancer cell lines. Therefore, the purpose of this study was to investigate the anti−cancer effect of aloe−emodin on human tongue squamous carcinoma SCC−4 cells. »
11/24/09

Docetaxel, cisplatin, and 5−flurouracil (DCF) administered every 3 weeks produces a high rate of treatment−related adverse events. The objective of the current study was to evaluate the efficacy and tolerability of a weekly formulation of DCF. »
01/27/10

Oral mucositis is frequent but serious adverse event associated with radiotherapy or radiochemotherapy in head and neck cancer, and severely impairs health−related quality of life, leading to poor prognosis due to discontinuation of the therapy. »
01/26/10

We studied the clinical characteristics and outcomes of patients undergoing pneumonectomy after preoperative concurrent chemoradiation for non-small cell lung cancer. »
01/24/10

Despite its feasibility and safety, use of video−assisted thoracic surgery (VATS) lobectomy for malignancies has spread slowly during the past decade because no definitive conclusions have been reached regarding the oncologic validity of this approach for malignancies. Thus, the purpose of this study was to analyze the indications and long−term results of VATS major pulmonary resections for primary lung cancers. »
02/01/10

To systematically review the evidence that smoking cessation after diagnosis of a primary lung tumour affects prognosis. Randomised controlled trials or observational longitudinal studies that measured the effect of quitting smoking after diagnosis of lung cancer on prognostic outcomes, regardless of stage at presentation or tumour histology, were included. »
01/21/10

Small cell lung cancer (SCLC) is a significant health problem worldwide because of its high propensity for relapse. »
01/26/10

The anti−epidermal growth factor receptor (EGFR) antibody cetuximab is efficacious in multiple tumor types. Patient selection with markers predictive of benefit may enhance its therapeutic index. This retrospective, correlative analysis of the phase III trial BMS099 of cetuximab in advanced non−small−cell lung cancer (NSCLC) was conducted to identify molecular markers for the selection of patients most likely to benefit from cetuximab. »
01/26/10